Carcinomaofrectum inodaidzwa kuti colorectal cancer, imota yakashata yakajairika mudumbu remukati, chiitiko chechipiri kune kenza yemudumbu uye esophageal, ndiyo inonyanya kupararira cancer colorectal (inenge 60%).Ruzhinji rwevarwere vane makore anopfuura makumi mana, uye vangangoita 15% vari pasi pemakore makumi matatu.Murume anowanzoonekwa, chiyero chemurume kumukadzi ndeye 2-3: 1 maererano nekuongorora kwekliniki, inowanikwa kuti chikamu chegomarara remukati chinoitika kubva kune rectal polyps kana schistosomiasis;kusingaperi kuzvimba kweura, zvimwe zvinogona kukonzera kenza;mafuta akawanda uye akakwirira-protein kudya kunokonzera kuwedzera kwecholic acid secretion, iyo yekupedzisira yakasvibiswa kuva unsaturated polycyclic hydrocarbons ne intestinal anaerobes, iyo inogonawo kukonzera kenza.