Musi wa10 Kurume, 2026, mushonga mutsva weB7-H3-targeting antibody-drug conjugate (ADC) YL201 wekubaiwa jekiseni, wakagadzirwa neMediLink Therapeutics, wakapihwa Breakthrough Therapy Designation neCenter for Drug Evaluation of China's National Medical Products Administration. Chiratidzo chakapihwa ichi chakabatanidzwa neSerplulimab yekurapa kenza yemapapu yemasero madiki (ES-SCLC) yekutanga.
YL201 iADC itsva inotarisa B7H3. Puroteni yeB7H3 inowanikwa zvakanyanya pamasero ane kenza uye masero anotanga kenza emhando dzakasiyana dzemabundu asi ine kuratidzwa kwakaderera munyama yakajairika, zvichiratidza kugona kwayo semushonga weADC. YL201 yakagadzirwa ichishandisa tekinoroji yeMediLink yeTumor Microenvironment Activable LINKer-payload (TMALIN®) yakabatana neB7H3 antibody chaiyo. Parizvino, YL201 iri kuongororwa mumhando dzakasiyana dzemabundu akasimba uye yakapinda mumiedzo yezvikamu zvakakosha muSmall Cell Lung Cancer neNasopharyngeal Carcinoma muChina.
### Ruzivo rwekiriniki rwechokwadi: Kushanda kwakakosha uye kuchengetedzeka kwakanaka
MunaKurume 2025, magazini yepamusoro-soro yepasi rose *Nature Medicine* yakaburitsa ruzivo kubva mukuyedzwa kwekiriniki kwePhase 1/1b kweYL201 muvarwere vane bundu rakasimba. Chidzidzo ichi, chaisanganisira varwere 312, chakaratidza:
- **Kushanda Kwazvo:** Pakati pevarwere 287 vaiongororwa, chiyero chekupindura chakanangana (ORR) chaive chinoshamisa ne40.8%, kusanganisira varwere vaviri vakapindura zvizere (CR) uye 115 vakapindura zvishoma (PR). Chiyero chekudzora chirwere (DCR) chakasvika 83.6%.
- **Kenza Yemapapu Yemasero Madiki Yakakura (ES-SCLC):** Muvarwere vakamborapwa ne platinum-based chemotherapy, ORR yaive 63.9%, DCR yaive 91.7%, uye avhareji yehupenyu husina progression-free survival (mPFS) yaive mwedzi 6.3.
- **Nasopharyngeal Carcinoma (NPC):** Pakati pevarwere makumi manomwe, ORR yaive 48.6%, DCR yaive 92.9%, nevarwere vaviri vakapindura zvizere. Nguva yepakati yekupindura (mDOR) yaive yakareba semwedzi 8.4.
Ruzivo urwu runosimbisa zvizere kushanda kwakasimba kwekurwisa bundu uye kuchengetedzeka kweYL201 mumhando dzakasiyana dzemabundu akasimba, zvichiisa hwaro hwakasimba hwekutsvaga kwekiriniki kunotevera uye kushandiswa kwakakura.
### Dhipatimendi reInternational Hospital Oncology reBeijing South Region: Bhiriji Renyu reMishonga Yepasirose
Dhipatimendi reBeijing South Region Oncology Hospital International rakagara rakazvipira kuunza matekinoroji ekurapa kenza anotungamira pasi rose uye mishonga. Tinonyatsotevera kufambira mberi kwekutsvaga uye tinoramba tichishanda pamwe chete nemasangano epamusoro esainzi munyika nekunze, tichiedza kupa varwere vekunze mukana wekuwana nzira dzekurapa dzinoshanda dzinosanganisira YL201.
Chikwata chedu cheInternational Patient Services chinogona kukupa zvinotevera:
- **Kuongororwa Kwekurapa Kwakasiyana:** Chikwata chevanhu vane hunyanzvi hwakasiyana-siyana (MDT) chichaongorora zvizere zvinyorwa zvako zvekurapa kuti chione kana kurapwa kweADC kwakakodzera chirwere chako.
- **Kuwana Rubatsiro Rwakapfava:** Rubatsiro pakuwana mavhiza ekuChina, kuronga mazano enyanzvi, kuronga mabasa ekuturikira, uye kuronga kupinda muchipatara kuti uwane ruzivo rusina kunetseka.
### Taura Nesu Izvozvi Kuti Uwane Ruzivo Rwakawanda
Kana iwe kana mumwe munhu waunoda ari kusangana nematambudziko ane chekuita nekenza yemapapu ine masero madiki, nasopharyngeal carcinoma, kana mamwe mabundu akaomarara, uye muchida kudzidza zvakawanda nezvekurapa kweADC kwazvino kana kuongorora mikana yekurapwa, ndapota taurai neBeijing South Region Oncology Hospital International Department nekukasika. Nyanzvi dzedu dzeInternational Patient Services dzichapindura mubvunzo wenyu mukati memaawa makumi maviri nemana.
**Ruzivo rwekuonana:**
- **Nhare:** 400-880-3716���
- **WeChat:** 17801183037
- **Email:**
100085_010@163.com
myimmnet@163.com
Tinonzwisisa kuti nzira yekurapa kenza yakaoma, asi budiriro yega yega inoratidza tariro itsva. Dhipatimendi reBeijing South Region Oncology Hospital International rinoda kumira nemi, richishandisa tekinoroji yezvekurapa yehunyanzvi uye kutarisirwa kwakanaka uye kwetsitsi, kuti mukunde kenza pamwe chete uye mugamuchire kutanga kwehupenyu.
Nguva yekutumira: Kurume-24-2026