Musi wa30 Chikumi, mushonga weAvistone weMET inhibitor wakazvigadzira wega weVebreltinib wakagamuchira mvumo kubva kuNational Medical Products Administration (NMPA) yekuChina yekurapa varwere vane kenza yemapapu isiri diki (NSCLC) iri munzvimbo yavo kana kuti ine MET amplification. Izvi zvinoratidza chiratidzo chechitatu chakatenderwa cheVebreltinib muChina uye mushonga wekutanga pasi rose we single-agent wakatenderwa kunyanya varwere veMET-amplified NSCLC.
Kubvumidzwa kweVebreltinib muChina kwechiratidzo chitsva ichi—kurapa varwere vane kenza yemapapu isiri diki (NSCLC) iri munzvimbo yavo kana kuti ine MET amplification—kwakavakirwa pamhedzisiro yakanaka kubva kuCohort 2 neCohort 3 yechidzidzo cheKUNPENG (NCT04258033).
Chikamu chechipiri chakanyoresa varwere vakamborapwa neMET-amplified NSCLC avo vakanga vakundikana kurapwa kwakajairika (kusanganisira platinum-based chemotherapy), nepo Chikamu chechipiri chaisanganisira varwere vasina ruzivo rwekurapwa neMET-amplified NSCLC vakaramba chemotherapy.
Varwere vanosvika 86 vane NSCLC yepamusoro kana kuti yakapararira munharaunda vakanyoreswa mumakoho ese ari maviri (33 muCohort 2 uye 53 muCohort 3). Zvakabuda muchidzidzo ichi zvakaratidza kuti huwandu hwemhinduro dzinoshanda (ORR) hwe48.8%, huwandu hwekutonga chirwere (DCR) hwe77.9%, huwandu hwemhinduro dzinoshanda (DoR) hwemwedzi 12.1, huwandu hwehupenyu husina kuenderera mberi (PFS) hwemwedzi 7.4, uye huwandu hwehupenyu husina kuenderera mberi (OS) hwemwedzi 13.9.
MuCohort 2 (varwere 33 vakamborapwa), ORR yaive 48.5%, DCR yaive 78.8%, avhareji yeDoR yaive mwedzi 11.0, avhareji yePFS yaive mwedzi 6.2, uye avhareji yeOS yaive mwedzi 11.7.
Muboka rechitatu (varwere 53 vasina ruzivo rwekurapwa), ORR yaive 49.1%, DCR yaive 77.4%, avhareji yeDoR yaive mwedzi 12.1, avhareji yePFS yaive mwedzi 8.3, uye avhareji yeOS yaive mwedzi 15.5.
Muchidzidzo cheKUNPENG, varwere makumi maviri nerimwe vane chirwere chepfungwa chebaseline brain metastases vakaongororwa neIndependent Review Committee (IRC). Pakati peizvi, gumi vakawana mhinduro dzakasimbiswa (PR), zvikaita kuti ORR ive ye47.6%, DCR ye85.7%, uye avhareji yeDoR yemwedzi gumi nerimwe. Pamusoro pezvo, avhareji yePFS neOS yaive mwedzi gumi nemana negumi ...
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
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Nguva yekutumira: Chikunguru-08-2025