VaX murwere ane makore ekuma40 akaonekwa aine acral melanoma. Mushure mekuvhiyiwa kwakanyanya mushure mekuonekwa kwavo muna 2015, mamiriro avo akaramba akasimba kwemakore mapfumbamwe. Zvinosuwisa kuti gore rapfuura, chirwere chavo chakadzokazve nekutapukirwa kwemapapu ese ari maviri. Pasinei nekuwana inguinal nepelvic lymph node dissection pamwe ne third-line systemic therapy (kusanganisira PD-1 antibody treatment uye NRAS mutation-targetted therapy), mabundu aya aibata zvakanyanya mapapu ese, chiuno, subcutaneous tissue yerudyi dundundu, uye bilateral erector spinae tsandanyama, zvichikonzera kurwadziwa kwakanyanya uye kudzikira kukuru kwehupenyu.
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Nhamba yeWeChat: 17801183037
Email：myimmnet@163.com
Pakutanga kwa2025, VaX vakapinda mukuyedzwa kwekiriniki kweTIL cell therapy (GC101) uye vakapedzisa TIL cell infusion kutanga kwaChikumi. Kunyangwe mutoro webundu ravo waive wakakura, negonda guru richisvika 62 mm, mavhiki matanhatu mushure mekuisirwa, maronda avo ese akadzikira ne31.9%, negonda rimwe chete guru richiderera neanenge 40%. Kushanda kwekurapa kwacho kwakasvika pachikamu chemhinduro (PR). Chinonyanya kukosha ndechekuti VaX havana kusangana nemhedzisiro yakaipa mushure mekurapa kweGC101 TIL, asi chete migumisiro yakajairika ine chekuita neimmunotherapy yakadai sekudzikira nefivha, iyo yakakurumidza kupera nekurapwa nezviratidzo.
Nezve GC101
GC101 mushonga weTIL TIL wakagadzirwa neJuncell Therapeutics uchishandisa chikuva chekuwedzera masero cheDeepTIL® cheDeepTIL®. DeepTIL® inoita kuti maTIL ave nesimba zvekuti hapana musanganiswa weIL-2 unodiwa mushure mekuiswa, uye simba rekurapwa kwekutanga rinogona kunge rakaderera.
Sekurapa kwekutanga kweTIL kunoda kurapwa kwakaderera uye kusina jekiseni reIL-2 pasi rose, GC101 yakasimbiswa nekuda kwekushanda kwayo mukurapa uye kuchengetedzeka kwayo izvo zvinovandudza zvikuru kuchengetedzeka uye kuwanikwa kweTIL therapy.
Nezve Melanoma
MuChina, huwandu hwevanhu vanofa nechirwere che melanoma hwakakwira uye huwandu hwevanhu vanofa nechirwere ichi huri kuwedzera gore negore. Zvichienzaniswa nevekuEurope kana vekuAmerica, kune musiyano mukuru muhunhu hwe melanoma muChinese: inenge 90% ye melanoma inobva paganda pakati pevekuEurope nevekuAmerica. MuAsia, inenge 50% ye melanoma inobva kumucheto wemuviri uye 20-30% mu mucous membrane. Kusiyana neizvi, melanoma yemhando ye front and mucosal ine fungidziro yakaipa.
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Nhamba yeWeChat: 17801183037
Email：myimmnet@163.com
Nguva yekutumira: Nyamavhuvhu-07-2025