Musi wa12 Chivabvu, 2025, CARsgen yakazivisa ruzivo rwekutanga rwekiriniki yeCT0596, iyo BCMA-target CAR-T yakagadzirwa ichishandisa THANK-u Plus™ platform. CT0596 iri kuongororwa pari zvino muongororo yekutanga yekiriniki yekuongorora relapse/refractory multiple myeloma (R/R MM) kana relapse/refractory plasma cell leukemia (R/R PCL) kuti ione kuchengetedzeka kwayo, uye kushanda kwayo kwekutanga.
Kubva musi wa6 Chivabvu, 2025, varwere vasere vane R/R MM avo vakamborapwa katatu kare vakanyoreswa uye vakapinzwa CT0596 mushure mekubviswa kwemasero eropa neFC regimen (fludarabine 22.5-30 mg/m² uye cyclophosphamide 350-500 mg/m²). Zvakawanikwa zvikuru kubva pamwedzi mina yekutevera zvinosanganisira:
Hapana zvakataurwa nezve chepfu dzinoderedza huwandu hwemushonga (DLTs), ≥Grade 3 cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), kana graft-versus-host disease (GVHD). Mushonga uyu wakaratidza kuchengetedzeka kwakanaka, pasina varwere vakarega kurapwa nekuda kwezviitiko zvakaipa.
1) Pakati pevarwere vashanu vakapedza bvunzo yekutanga yekushanda zvakanaka paVhiki rechina, varwere vatatu (60%) vakawana mhinduro yakakwana (sCR/CR), uye varwere vana (80%) vakawana chirwere chidiki chekare (MRD) - negativity mumongo wemapfupa. 2) Ruzivo rwekutanga rwekushanda zvakanaka kubva kuvarwere vaviri paZuva rechi14 rwakaratidza kudzikira kwemaronda anoyerwa ne ≥92% uye ≥65%, zvichiteerana. 3) Murwere mumwe chete akanga asati asvika panguva yakatarwa yekuongorora kushanda zvakanaka.
Varwere vese vane sCR/CR vakaramba vachipindura, kusanganisira murwere wekutanga akapedza mwedzi mina yekutevera.
Zvichibva padata rekutanga rekuchengetedza uye kushanda zvakanaka, CT0596 yakaratidza kushivirira kwakanaka uye kukurudzira zviratidzo zvekushanda zvakanaka muvarwere veR/R MM pamatanho ese akatarwa, nekuwedzera kweCAR-T kwakaonekwa. Izvi zvinoda kuongororwa kwakawanda kwete muR/R MM chete, asiwo mune mamwe marara emasero eplasma uye zvirwere zve autoimmune zvinokonzereswa nemasero eplasma anoshanda.
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Email：myimmnet@163.com
Nguva yekutumira: Chivabvu-15-2025