PLB1004, yakagadzirwa neBeijing Avistone Biotechnology Co., Ltd., mushonga wakachengeteka, unosarudza zvakanyanya, uye unoshanda zvakanaka we tyrosine kinase inhibitor (EGFR-TKI) unoshandiswa kurapa kenza yemapapu isiri yemasero madiki (NSCLC).
Musi wa9 Kubvumbi, 2025, National Medical Products Administration Drug Evaluation Center (CDE) yakaratidza kuti PLB1004 yeBeijing Avistone Biotechnology yaifanirwa kuverengerwa mukurapa kwevarwere vane kenza yemapapu yeMETastatic non-small cell (NSCLC) avo vaive neEGFR mutation, vakasangana nekuwedzera uye/kana kuwedzera kwehuwandu hwemasero mushure mekukundikana kwekurapwa kweEGFR-TKI.
Mhedzisiro yekutanga yePLB1004 yakabatanidzwa neVebreltinib mukurapa varwere vekenza yemapapu vasiri masero madiki vane EGFR mutations, MET amplification kana MET overexpression mushure meEGFR-TKI yakaziviswa pa2024 World Conference on Lung Cancer.
Varwere makumi mana nevana vakagamuchira Vebreltinib 100mg pamwe nePLB1004 160mg (n=15), Vebreltinib 150mg pamwe nePLB1004 160mg (n=13), Vebreltinib 200mg pamwe nePLB1004 80mg (n=3), kana Vebreltinib 150mg pamwe nePLB1004 80mg (n=13) uye vakabatanidzwa muongororo yese yekuchengetedza. Pakati pevarwere makumi mana nevana vakaongororwa, 36.4% yevarwere vaive nemetastases yeuropi uye 86.4% yevarwere vakambogamuchira EGFR-TKI yechizvarwa chechitatu, zvichiteerana. Mhinduro dzakanangana dzakaitika kune ese madhigirii eVebreltinib nePLB1004 akaedzwa, nemhinduro dzisina kukwana (PRs) dzakaonekwa muvarwere 19/32 (59.4%) vanoongororwa mhinduro. Pakati pevarwere vane metastases yeuropi, ORR yaive 75.0% (9/12). ORR yaive 58.6% (17/29) muvarwere vakagamuchira EGFR-TKI yechizvarwa chechitatu. MaTRAE ainyanya kuwanikwa aive mapundu uye paronychia. Hapana varwere vakarega kurapwa nekuda kweTRAEs.
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Email：myimmnet@163.com
Nguva yekutumira: Kubvumbi-10-2025