Musi wa31 Chikunguru, AstraZeneca neMerck & Co. vakazivisa pamwe chete kuti mushonga wavo wePARP inhibitor Lynparza, pamwe chete neAbiraterone neprednisolone, wabvumidzwa muChina kurapa varwere vakuru vane metastatic castration-resistant prostate cancer (mCRPC) vane germline kana somatic BRCA mutations (gBRCAm kana sBRCAm).
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
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Lynparza (olaparib) mushonga wekutanga mukirasi yePARP inhibitor uye mushonga wekutanga wakanangana nekudzivirira mhinduro yekukuvara kweDNA (DDR) mumasero/mamota ane kushomeka kweHRR, senge shanduko muBRCA1 uye/kana BRCA2. Kudziviswa kwePARP neLynparza kunotungamira mukubatwa kwePARP yakasungirirwa kuDNA single-strand breaks, kumira kwemaforogo ekubereka, kuparara kwawo uye kugadzirwa kweDNA double-strand breaks uye kufa kwemasero ekenza.
Kubvumidzwa uku kwakavakirwa zvakanyanya pamhedzisiro yekuongorora kwemapoka madiki kubva kumapoka epasi rose neChina ekuyedzwa kwePROpel Phase III. PROpel iongororo yekiriniki yePhase III isina kurongeka, ine mapofu maviri, ine nzvimbo dzakawanda inoongorora kushanda, kuchengetedzeka, uye kushivirira kweLynparza pamwe chete neAbiraterone neprednisolone zvichienzaniswa neplacebo pamwe neAbiraterone neprednisolone muvarwere vechirume vane mCRPC vasina kugamuchira chemotherapy kana novel hormonal therapy (NHA) padanho remCRPC.
Ruzivo rwakabva kuboka repasi rose revarwere vane BRCA mutations rwakaratidza kuti Lynparza pamwe chete neAbiraterone yakaratidza kuvandudzika kwakakosha mukurarama pasina progression-free survival (rPFS) kana tichienzanisa neAbiraterone monotherapy. Kuongororwa kwevarwere vane BRCA mutations muboka repasi rose kwakaratidza kuti Lynparza pamwe chete neAbiraterone zvakaderedza njodzi yekufambira mberi kwechirwere kana kufa ne76% uye njodzi yekufa ne70%. Avhareji yerPFS uye avhareji yekurarama kwese (OS) muboka reLynparza pamwe neAbiraterone yakanga isati yasvika, nepo avhareji yerPFS uye avhareji yeOS muboka reAbiraterone monotherapy yaive mwedzi misere nemwedzi makumi maviri nematatu, zvichiteerana.
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Nhamba yeWeChat: 17801183037
Email：myimmnet@163.com
Nguva yekutumira: Nyamavhuvhu-07-2025