Musi wa31 Kurume, 2026, Center for Drug Evaluation of China's National Medical Products Administration yakapa nhau dzinonakidza: GFH375, yakagadzirwa neGenFleet Therapeutics, yave pamutemo kubatanidzwa se "Breakthrough Therapy" yekurapa varwere vane kenza yepancreatic yakapararira ine KRAS G12D mutation avo vakamborapwa kamwe chete kare. Izvi zvinoratidza danho rakakosha mukurapa kenza yepancreatic nenzira chaiyo.
Kana iwe kana mumwe munhu waunoda ari kutambura nekenza yepancreatic yeKRAS G12D-mutant, musarasa tariro. Dhipatimendi reBeijing South Region Oncology Hospital International Department (400-880-3716) riri kutevera zviri kuitika padanho iri uye rinopa mazano ehunyanzvi uye mabasa ekubatanidza kurapwa kwevarwere vekune dzimwe nyika.
**Nezve GFH375/VS-7375**
GFH375 mushonga unoshanda nemuromo, une simba, uye unosarudza zvakanyanya KRAS G12D (ON/OFF) inhibitor yakagadzirirwa kunanga kuchinjana kweGTP/GDP, nokudaro ichikanganisa kushanda kwenzira yekubuda nayo uye ichidzivirira kukura kwemasero egomarara. Zvidzidzo zvepamberi pekiriniki zvakaratidza kudziviswa kunoenderana nedosi mumamodheru ane mutations dzeKRAS G12D; GFH375 yakaratidzawo njodzi shoma kubva kuchinangwa mukusarudza kwechinase uye kuyedzwa kwekuchengetedza chinangwa.
GenFleet yakabatana neVerastem Oncology (Nasdaq: VSTM) kuti ifambise mberi zvirongwa zvitatu zvitsva zvekenza zvinotarisa kenza dzinotungamirirwa neRAS/MAPK. Kubatana uku kunopa Verastem sarudzo yakasarudzika yekuwana rezenisi yeimwe neimwe yemishonga mitatu mushure mekupedza kubudirira kwematanho akatarwa mukuyedza kwePhase I. Muna Zvita 2023, Verastem yakasarudza GFH375/VS-7375, mushonga weKRAS G12D (ON/OFF) unodzivisa, sechirongwa chayo chikuru kubva mukubatana, uye rezenisi yeGFH375 yakashandiswa muna Ndira 2025 ndiyo yaive yekutanga kubva mukubatana uku. Marezenisi aya anopa Verastem kodzero dzekuvandudza nekutengesa kunze kweChina, nepo GenFleet ichiramba iine kodzero mukati meChina.
**Ruzivo rwekiriniki rwechikamu chekutanga/chipiri rwunovimbisa rwakapihwa pamusangano we2025 ESMO:**
- 91.5% yevarwere vakanzwa kudzikira kwemaronda aidiwa
- Mwero wekupindura kwakanangana (ORR) wakasvika 40.7%
- Chiyero chekudzivirira zvirwere (DCR) chakakwira kusvika pa96.7%
- Kurarama kwepakati pasina kufambira mberi (mPFS) kwaive kwemwedzi 5.52
- Mwero wekurarama usina kufambira mberi kwemwedzi mina waive 78.2%
Ruzivo urwu, rwakabva kuvarwere makumi mashanu nevapfumbamwe vane KRAS G12D-mutant pancreatic ductal adenocarcinoma (PDAC) yakamborapwa, runoratidza zvakasimba kushanda kweGFH375 pakurwisa bundu mukenza yepancreatic isingashande.
**Sei Uchifanira Kusarudza Dhipatimendi Repasirose reBeijing South Region Oncology Hospital?**
Senzira yekutanga mumabasa ekurapa epasi rose, Dhipatimendi reBeijing South Region Oncology Hospital International rakatsunga kupa varwere vepasi rose zvinotevera:
- Kubvunzana nenyanzvi dzezvekurapa nemabasa ekugadzwa kwemisangano mumitauro yakawanda
- Kuwana nyanzvi dzepamusoro dzekenza muChina nemunyika dzese
- Nzira imwe chete yekurapa yakapoteredza miganhu
Tinonzwisisa kuti kune varwere vane kenza yakanyanya kukura, zuva rega rega rekumirira rinounza njodzi huru. Nokudaro, takagadzira nzira dzakawanda dzekutaurirana dzepasi rose dziri nyore kuti tive nechokwadi chekuti munowana rutsigiro rwenyanzvi panguva yakakodzera.
**Tibatei nhasi mutange rwendo rwenyu rwetariro**
��� Nhare yekukurumidza: 400-880-3716
��� WeChat: 17801183037
��� Tsamba yemagetsi:
- 100085_010@163.com
- myimmnet@163.com
Hazvina mhosva kuti uri munyika ipi kana dunhu ripi, kana kuti wakamboedza nzira dzakawanda dzekurapa, Dhipatimendi reBeijing South Region Oncology Hospital International rakagadzirira kukubatsira mukurwisa kenza. Kubudirira kweGFH375 kungave kuri chiedza chawanga wakamirira.
Call 400-880-3716, add us on WeChat at 17801183037, or email us at 100085_010@163.com or myimmnet@163.com.
Pamwe chete, ngatiedzei kuwana mikana yakawanda yehupenyu.
> Cherechedza: GFH375 haisati yatenderwa zviri pamutemo kuti itengeswe munyika yeChina. Kusarudzwa kwayo kweBreakthrough Therapy kunotarisirwa kukurumidzisa kuwanikwa kwemishonga. Dhipatimendi reBeijing South Region Oncology Hospital International richanyatso tarisa kufambira mberi kwekushandiswa kwemishonga uye kupa ruzivo nezvekurapa kwemazuva ano uye masevhisi ekubatanidza varwere vanokodzera. Ndokumbirawo mutevedzere gwara rachiremba wenyu maererano nehurongwa hwekurapa hwakasiyana.
Nguva yekutumira: Kubvumbi-10-2026