Musi wa22 Nyamavhuvhu, 2025, Datopotamab deruxtecan (Dato-DXd; Datroway) yakagamuchirwa muChina kuti irapwe varwere vakuru vane kenza yemazamu isingabvisike kana kuti ine metastatic hormone receptor–positive, HER2-negative (immunohistochemistry [IHC] 0, IHC 1+, kana IHC 2+/in situ hybridization [ISH] negative) avo vakambogamuchira endocrine therapy uye kanenge ka1 line ye chemotherapy mumamiriro ezvinhu epamusoro.
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Nhamba yeWeChat: 17801183037
Email：myimmnet@163.com
Kubvumidzwa uku kwakavakirwa pamhedzisiro yakanaka yechidzidzo chepasi rose chePhase III TROPION-Breast01. Chidzidzo chepasi rose, chechikamu chechitatu, chakavhurika, chakasarudzika cheTROPION-Breast01 chakaongorora trophoblast cell surface antigen 2-directed antibody-drug conjugate datopotamab deruxtecan (Dato-DXd) zvichienzaniswa nesarudzo yemuongorori yechemotherapy (ICC) mukenza yemazamu yereceptor–positive/human epidermal growth factor receptor 2–negative (HR+/HER2–).
Varwere vakaiswa muDato-DXd (n = 365) kana ICC (n = 367). Dato-DXd yakaderedza zvakanyanya njodzi yekufambira mberi kana kufa zvichienzaniswa neICC (PFS neBICR hazard ratio [HR], 0.63 [95% CI, 0.52 kusvika 0.76]; P < .0001). Kubatsira kwePFS kwakaramba kuripo kwakaonekwa mumapoka madiki. Kunyangwe data reOS rakanga risati rakura, maitiro aifarira Dato-DXd akaonekwa (HR, 0.84 [95% CI, 0.62 kusvika 1.14]). Mwero wezviitiko zvakashata zvine chekuita nekurapwa (TRAEs) zvegiredhi ≥3 neDato-DXd waive wakaderera pane ICC (20.8% v 44.7%). MaTRAE akajairika (chero giredhi; giredhi ≥3) aive kurutsa (51.1%; 1.4%) uye stomatitis (50%; 6.4%) neDato-DXd uye neutropenia (yakarongwa, 42.5%; 30.8%) neICC.
Varwere vaigamuchira Dato-DXd vakave nekuvandudzika kwakakosha uye kwakakosha muPFS uye kuchengetedzeka kwavo kwakanaka uye kunogoneka, zvichienzaniswa neICC.
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Nhamba yeWeChat: 17801183037
Email：myimmnet@163.com
Nguva yekutumira: Nyamavhuvhu-26-2025