Musi wa21 Kurume, 2025, Immunofoco yakazivisa kuti EpCAM-targeting autologous CAR-T cell therapy yayo yakazvimiririra, IMC001, yakapihwa mvumo neCenter for Drug Evaluation (CDE) pasi peNational Medical Products Administration (NMPA) kuChina kuti ishandise mushonga wayo wechipiri weInvestigational New Drug (IND), ine nhamba yekugamuchirwa yeCXSL2400901. Chirongwa ichi cheIND chakanangana nekurapa EpCAM-positive epithelial advanced solid tumors. Kare, IMC001 yakawana mvumo yeIND muChina nemuUnited States muna Kukadzi 2024 yekurapa EpCAM-positive advanced gastrointestinal tumors.
Molekyuru yekunamatira kwemasero eEpithelial (EpCAM) inoratidzwa zvakanyanya pamatishu akasiyana-siyana egomarara rinobva muepithelial, kusanganisira kenza yemudumbu, kenza yedumbu, kenza yepancreas, kenza yemudumbu, kenza yemapapu, kenza yemudumbu, uye kenza yemazamu. Kusiyana neizvi, kuratidzwa kwayo kwakaderera mumatishu akajairwa. Pasinei nematambudziko akadai sekuoma kwenzvimbo ine gomarara rakasimba uye kusiyana kwezvinangwa, IMC001 yakaratidza kuchengetedzeka kwakanaka uye kushanda kwekutanga mumiedzo yekutanga yekiriniki yemagomarara emudumbu, nekuda kwekusarudza kwayo kwakasarudzika chinangwa uye dhizaini yayo itsva. Ichi chiratidzo chekuwedzera chinangwa chekuongorora kugona kwayo kwekiriniki.
Mumashoko ekuratidzira pamisangano yeASCO neCSCO ya2024, data reIIT rekiriniki reIMC001 rakaratidza kuti pakati pevarwere gumi vaiongororwa vane kenza yemudumbu yakakwira, huwandu hwevarwere vairwara hwaive 90%, murwere mumwe chete muboka redosi shoma aive 33.3% uye vaviri muboka redosi yepakati vaive 40% vakawana mhinduro isina kukwana (PR). Kurarama kwepakati (OS) muboka redosi yepakati kwakapfuura mavhiki makumi mashanu nemashanu. Murwere mumwe chete muboka redosi yepakati akawana PR yakasimbiswa pakupera kwevhiki rechi24, zvichikonzera kubviswa kwegastrectomy pavhiki rechi27, uye murwere akararama kwemwedzi inopfuura makumi maviri nemiviri panosvika zuva rekupedzisira.
Kubviswa kweIND iyi yekuwedzera kunomiririra danho guru mukuwedzera chiyero chekuongorora kwekiriniki cheIMC001 kubva kumabundu emudumbu kusvika kune akasiyana-siyana emabundu akaoma e epithelial, anosanganisira kenza yemapapu yemasero madiki (SCLC), kenza yemazamu ine triple-negative (TNBC), nezvimwe zvirwere zvegomarara.
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Email：myimmnet@163.com
Nguva yekutumira: Kubvumbi-03-2025