Munguva pfupi yapfuura, ongororo yeAntengene's Phase I/II CLINCH yeATG-022 (CLDN18.2 antibody-drug conjugate), murwere akwegura ane kenza yemudumbu yakakwira uyo akafambira mberi pakurapa mishonga yakawanda, immunotherapy uye kurapwa kwakanangana nemetastases yakawanda akawana mhinduro yakakwana (CR) mushure meATG-022 monotherapy. Mamiriro emurwere uyu haana bundu akasimbiswa nePET/CT muna Chivabvu 2025.
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Nhamba yeWeChat: 17801183037
Email：myimmnet@163.com
ATG-022 iCLDN18.2 ADC yakawanikwa uye yakagadzirwa neAntengene. Pamusangano weASCO GI 2025 pakutanga kwegore rino, Antengene yakapa data rekiriniki rakagadziridzwa reATG-022. Muvarwere vane CLDN18.2 expression iri pakati nepakati kusvika yakakwira (IHC 2+ ≥ 20%), chiyero chekupindura chakanangana (ORR) chaive 42.9%, uye chiyero chekudzora chirwere (DCR) chaive 95.2%. Pakati pevarwere vane CLDN18.2 expression yakaderera (IHC 2+ < 20%), ORR yaive 30.0%, uye DCR yaive 50.0%. Data iri rinoratidza kuti ATG-022 inopa kushanda kwakanaka mukiriniki uye kuchengetedzeka kwakanaka muzvikamu zvakasiyana-siyana zveCLDN18.2 expression, kusanganisira expression yakakwira, yakaderera, uye kunyange yakaderera zvakanyanya. Kushanda kwayo mukurwisa bundu kunoratidza kuti ATG-022 inogona kupa mabhenefiti ekurapa kuvarwere vakawanda zvichienzaniswa nedzimwe nzira dzekurapa dzinoshandiswa neCLDN18.2. Parizvino, chidzidzo chekuwedzera huwandu hweATG-022 chiri kuenderera mberi munyika yeChina neAustralia.
Kubudirira uku kweCR mumurwere uyu akwegura ane kenza yemudumbu kunokurudzira zvikuru, zvichiratidza kugona kweATG-022 kurapa senzira itsva yekurapa yeADC. Zvakakosha, iyi haisiyo yega CR yakaonekwa muchidzidzo chiri kuenderera mberi. Kusvika pari zvino, nyaya nhatu dzeCR dzakaonekwa, kusanganisira varwere vanobva kuChina neAustralia. Antengene inotarisira kupa ruzivo rwakagadziridzwa kubva muchidzidzo cheATG-022 pamusangano weESMO uri kuuya muna Gumiguru 2025.
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Nhamba yeWeChat: 17801183037
Email：myimmnet@163.com
Nguva yekutumira: Nyamavhuvhu-21-2025