Muna 2021, murwere ane makore 67 ekuberekwa ane kenza yepancreas akaita chishamiso chekurapa. Mushure mekuvhiyiwa, kurapwa kakawanda nechemotherapy, uye kukundikana kweTIL therapy, kuyedzwa kwekiriniki kweTCR-T kwakaitwa.Kurapa nemasero kwaakaita kwakaita kuti kupararira kwemasero mumapapu kuderere ne72% mukati memwedzi mitanhatu. Mhedzisiro iyi yakabuda muNew England Journal of Medicine, ichiunza tariro itsva kuvarwere vane bundu rakasimba pasi rese.
Nzvimbo yeInternational Consultation Center yeBeijing South Suburb Oncology Hospital (400 – 880 – 3716) inogona kuvaka zambuko rekurapa kwepamusoro-soro kwevarwere pasi rose nekuda kwezviwanikwa zvayo zvepasi rose uye inoita basa rakakosha mukubvunzana kwepasi rose nekurapwa kwevarwere.
Nezve TCR-TKurapa
TCR-TKurapa nemasero, zita rayo rakazara rinonzi T – cell receptor engineered T – cell therapy, inzira itsva yekurapa nekudzivirira masero. Musimboti wayo mukuru ndeyekubvisa masero eT mumuviri wemurwere uye kuisa gene reTCR rinogona kuziva maantigen chaiwo egomarara mumasero eT kuburikidza netekinoroji yekugadzira majini. Nekuda kweizvozvo, masero eT akagadziriswa anogona kuziva nekusunga nemazvo maantigen ari pamusoro pemasero egomarara, nokudaro achibatsira kuuraya masero eT uye kuzadzisa chinangwa chekubvisa masero egomarara.
Nyaya Yekubudirira kweTCR-TKurapa: Chishamiso cheMurwere ane KRAS G12D - Mutated Pancreatic Cancer
Asati aonekwa kuti ane pancreatic head adenocarcinoma, murwere uyu ane makore 67 ekuberekwa akatambura zvakanyanya nekuda kwekurwiswa kakawanda kwepancreatitis uye biliary stricture. Mushure mekuongororwa, akaongororwa kane madenderedzwa mana eFOLFIRINOX neoadjuvant chemotherapy, zvichiteverwa nekuvhiyiwa rese uye kumwezve chemotherapy. Izvi zvakaita kuti mamiriro ake adzorerwe kwenguva yakati, uye bundu harina kuramba richienderera mberi.
Zvisinei, nguva dzakanaka hadzina kugara kwenguva refu. Muna 2019, murwere akatanga kurwara nemapapu, izvo zvisina mubvunzo zvakakonzera dambudziko guru pakurapwa. Muna 2020, akapinda mukuyedzwa kwekiriniki kwegomarara - kupinda muropa remalymphocyte, asi mwedzi mitanhatu gare gare, maronda emapapu akaenderera mberi zvakare, zvichiratidza kuti nzira dzekurapa dzakamboshandiswa kare hadzina kukwanisa kudzora kukura kwegomarara.
Murwere paakanga ava kuda kuora mwoyo, muna Chivabvu 2021, US Food and Drug Administration yakabvumidza chikumbiro chitsva chekutsvaga mishonga, icho chakava chinhu chakakosha muhupenyu hwake - akaunzwa kuTCR-T.kurapwa nemasero. Muna Chikumi 2021, akapihwa kurapwa kwemasero eropa remuviri wake (T-cell). Zvinoshamisa kuti, mwedzi mumwe chete mushure mekuiswa kwemasero, maronda emapapu emurwere akadzikira zvakanyanya, uye bundu racho rakaderera ne62%. Mushure mehafu yegore, bundu racho rakadzikira ne72%.
Mugumisiro uyu unoshamisa wekurapa unoratidza zvizere kugona kukuru kweTCR-Tkurapwa nemasero mukurapa kenza.
Kune varwere vegomarara, kuwana chirwere chakarurama uye chirongwa chakanakisa chekurapa kwakakosha. Zvisinei, nekuda kwekusiyana kwemazinga ekurapa uye matekinoroji munzvimbo dzakasiyana, varwere vangasakwanisa kuwana mazano ekurapa epamusoro-soro munharaunda. Kubvunzana kwenyika dzese kunopa varwere mukana wekutaurirana nenyanzvi dzepamusoro dzepasi rose, zvichivabatsira kudzidza nezvenzira dzekurapa dzichangoburwa uye mhedzisiro yekutsvagisa pasi rese.
Kuburikidza nekubvunzana kwenyika dzakasiyana-siyana, varwere vanogona kuongororwa nenyanzvi dzakasiyana-siyana kubva kunyika dzakasiyana siyana nenzvimbo dzakasiyana. Nyanzvi idzi dzine ruzivo rwakakura mukurapa uye ruzivo rwehunyanzvi uye dzinogona kuongorora nekutonga mamiriro emurwere kubva pamaonero akasiyana kuti dzigadzire zvirongwa zvekurapa zvakananga uye zvakananga.
Pamusoro pezvo, kubvunzana kwenyika dzepasi rose kunogonawo kubatsira varwere kudzidza nezvemimwe miedzo yekiriniki uye nzira dzekurapa dzisati dzaitwa muChina, zvichivapa dzimwe nzira dzekurapa.
Dhipatimendi reInternational Department of Beijing South Suburb Oncology Hospital (400 – 880 – 3716) rinoziva kukosha kwekubvunzana kwevarwere vegomarara pasi rose. Nokudaro, rinovaka puratifomu yekudyidzana kwekurapa pasi rose kuti ripe varwere mabasa ehunyanzvi uye anoshanda ekubatsirana pasi rose. PaInternational Department of Beijing South Suburb Oncology Hospital, varwere vanogona kutora chikamu mukubvunzana kwepasi rose online kana offline. Chikwata chedu chekurapa chichaunganidza zvinyorwa zvekurapa zvemurwere, mishumo yebvunzo nerumwe ruzivo pachine nguva uye chozvishandura muchiRungu kuti chive nechokwadi chekuti nyanzvi dzepasi rose dzinogona kunzwisisa zvizere mamiriro emurwere. Munguva yekubvunzana, nyanzvi dzepasi rose dzichataurirana chiso nechiso nemurwere, dzobvunza mibvunzo yakadzama nezvenhoroondo yekurapa kwemurwere, zviratidzo, nemamiriro ekurapwa, uye dzozobatanidza mhedzisiro yetsvakiridzo yezvekurapa yazvino uye ruzivo rwekiriniki kuti vagadzire hurongwa hwekurapa hwakakodzera murwere.
Panguva imwe chete, Dhipatimendi rePasirose reBeijing South Suburb Oncology Hospital richapawo varwere mabasa ekushandura nekubatanidza mabasa avo kuti vaone kuti kubvunzana kwacho kuri kufamba zvakanaka. Mushure mekubvunzana, tichakurumidza kupa murwere mhinduro dzemhinduro dzekurapwa uye mazano ekurapwa uye kupa gwara rekutevera nerutsigiro rwekurapwa.
Kuti varwere vakwanise kuwana mazano ekuongorora nekurapa kubva kunyanzvi dzepasi rose nekukurumidza, Dhipatimendi reInternational Department reBeijing South Suburb Oncology Hospital rakarerutsa maitiro ebasa rekubvunzana. Varwere vanongoda kufonera 400 - 880 - 3716 vopa zvinyorwa zvekurapa zvakakodzera uye mishumo yekuongororwa. Chikwata chehunyanzvi cheDhipatimendi reInternational Department reBeijing South Suburb Oncology Hospital chicharonga nyanzvi yepasi rose yakakodzera kuti murwere abvunze mukati menguva pfupi. Munguva yekubvunzana, timu yehunyanzvi yekushandura ichaita kuti kutaurirana kwakanaka uye kwakarurama pakati pevanachiremba nevarwere, zvichiita kuti varwere vanzwisise zvakajeka mafungiro nemazano enyanzvi. Pamusoro pezvo, Dhipatimendi reInternational Department reBeijing South Suburb Oncology Hospital rinogonawo kubatsira varwere mukubata maitiro ekutumira varwere, kuronga mafambiro, nezvimwewo, kupa masevhisi ekumira kamwe chete.
Kugovana Nyaya uye Kufuridzirwa
Kuwedzera kune nyaya yataurwa pamusoro apa yemurwere ane KRAS G12D - kenza yepancreatic yakachinja, Dhipatimendi reInternational Department reBeijing South Suburb Oncology Hospital rakabatsirawo varwere vegomarara vekune dzimwe nyika kuwana mhedzisiro yakanaka yekurapwa kuburikidza nekurapwa muChina.
Muna Chikumi 2024, murwere wekenza yemapapu asiri masero madiki anobva kuNorth Korea akakumbira rubatsiro kwatiri. Kenza yemapapu ndeimwe yemabundu ane huwandu hwakanyanya hwezvirwere pasi rose nemuChina. Muna 2022, kwaive nevanhu vanosvika mamiriyoni 1.06 vane chirwere chitsva uye vanhu vanosvika zviuru mazana manomwe nemakumi mana vakafa nekenza yemapapu muChina, pakati pavo kenza yemapapu isiri masero madiki (NSCLC) inokwana 80% - 85%.
Murwere wacho aive neEGFR mutation uye akanga awana kurapwa kwakadai seafatinib neosimertinib. Kunyangwe akanga agamuchira kurapwa kwakasiyana-siyana, mashoko akaipa akaramba achiuya muna Chivabvu 2024, uye mamiriro emurwere akafambira mberi. Saka akauya kuChina kuti atibatsire.
Mushure mekuongororwa, kuonekwa kwemesothelin (MSLN) yemurwere kwaive 75%. Takabva tabatsira murwere kuwana hurongwa hwekurapa hutsva munyika yese. Iye zvino mamiriro emurwere aderera, uye maronda emapapu aderera, sezvakaratidzwa mumufananidzo uri pazasi.
Nyaya iyi inotiudza kuti kune varwere vegomarara, havafanirwe kurega mukana wekurapwa zviri nyore. Kunyangwe kana kurapwa kwemumba kuri mudambudziko, vanogonawo kunzwisisa nzira dzekurapa dzepasi rose dzazvino uye mhedzisiro yekutsvagisa kuburikidza nekubvunzana kwenyika dzese uye vanoedza kuwana mikana yakawanda yekurapwa ivo pachavo.
Maitiro Ekutaura neDhipatimendi Repasi Pose reBeijing South Suburb Oncology Hospital
Kana iwe kana nhengo dzemhuri yako muchirwara negomarara uye muchitarisira kudzidza nezvenzira dzekurapa dzepasi rose kana kutsvaga mazano ekuongorora nekurapa kubva kunyanzvi dzepasi rose, ndapota fonerai nhamba yefoni yeInternational Department of Beijing South Suburb Oncology Hospital (400 – 880 – 3716). Chikwata chehunyanzvi chichapindura mibvunzo yenyu, choronga mazano epasi rose, uye chokupai rutsigiro rwakazara nerubatsiro.
Kurapa kenza ihondo yakareba uye yakaoma, asi tinotenda kuti nekufambira mberi kuri kuitwa tekinoroji yekurapa, varwere vekenza vakawanda vachakwanisa kukunda chirwere ichi vowana hutano hwakanaka. Dhipatimendi reInternational Department reBeijing South Suburb Oncology Hospital richaramba richiedza kuramba richivandudza hunyanzvi hwaro hwebasa uye hunyanzvi hwekurapa uye kupa rubatsiro rwepamusoro-soro rwekurapa rwepasi rose kune varwere vekenza vakawanda. Ngatishandei pamwe chete kurwisa kenza pamwe chete uye kugadzira zvishamiso zvehupenyu!
Parizvino, kuchine miedzo yakawanda yekiriniki yehunyanzvi hutsva hwekurwisa gomarara muChina huri kutsvaga varwere. Kana muchida kubvunzana nezvemishonga mitsva netekinoroji, munogona kubata Dhipatimendi reBeijing South Region Oncology Hospital International.
Nhamba yefoni: 4008803716
Email：myimmnet@163.com
Nguva yekutumira: Chivabvu-15-2025